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MCAO (Middle Cerebral Artery Occlusion) Sutures

MCAO sutures for rodent stroke models. MCAO (middle cerebral artery occlusion) sutures for inducing ischemic stroke models in rats and mice.

MCAO sutures are silicone-rubber coated nylon monofilaments, in which the silicone-rubber coating is engineered for ensuring a complete occlusion of the middle cerebral artery (MCA) origin while avoiding subarachnoid hemorrhage (SAH). Doccol MCAO sutures have been well recognized and preferably selected by stroke investigators for inducing ischemic stroke models.


Using Doccol monofilaments for inducing MCAO models has been widely accepted as a necessary technical step and also a new standard for ensuring the highest quality of stroke modeling. MCAO sutures are available in nylon monofilament material USP size 3-0, 4-0, 5-0, 6-0, 7-0, and 8-0; diameters of silicone-rubber coated part range from 0.15 mm to 0.58 mm; coating lengths are available from 1.5 mm to 10 mm. Using Doccol monofilaments for inducing MCAO models has been reported to be able to drastically decrease the within-group variation of stroke models, reducing the standard deviation (SD) to 5% of the mean value for infarction volume. For more information please read Doccol Made a Difference in Stroke Modeling. Doccol also provides sorted MCAO sutures of different diameters and coating lengths (SSK series) for surgeons to find out their optimal MCAO sutures.

Doccol products are referred by over a thousand scholarly articles. Customer include top-ranked universities, highly prestigious research institutes, and world-leading pharmaceutical companies from all over the world.

MCAO sutures are available in nylon monofilament material USP size 3-0, 4-0, 5-0, 6-0, 7-0, and 8-0, which are categorized first by coating diameter, then further by coating length. We provide a match chart below to help you select coating diameters:
 

Animal Body
Weight (g)

Suggested 
tip Diameters (mm)

Bare filament 
USP “0”

12-15

0.15, 0.17

8-0, 7-0

15-20

0.17, 0.19

8-0, 7-0

21-25

0.21, 0.22

8-0, 7-0, 6-0

26-30

0.22, 0.23

8-0, 7-0, 6-0

31-35

0.23, 0.24

8-0, 7-0, 6-0

36-200

0.24 - 0.33

5-0, 6-0

201-250

0.33, 0.35

5-0, 4-0

251-280

0.35, 0.37

5-0, 4-0

281-330

0.37, 0.39

5-0, 4-0

331-400

0.41

4-0, 3-0

401-500

0.43, 0.45

4-0, 3-0

501-600

0.47, 0.49

4-0, 3-0

601-700

0.51, 0.54

3-0

701-800

0.54

3-0

801-900

0.54, 0.58

3-0

901-1000

0.58

3-0

 

MCAO sutures for the following tip (coated part) diameters:

 


Diameter 0.15mm

Diameter 0.17mm

Diameter 0.18mm

Diameter 0.19mm

Diameter 0.20mm

Diameter 0.21mm

Diameter 0.22mm

Diameter 0.23mm

Diameter 0.24mm

Diameter 0.25mm

Diameter 0.26mm

Diameter 0.27mm

Diameter 0.29mm

Diameter 0.31mm

Diameter 0.33mm

Diameter 0.35mm

Diameter 0.36mm

Diameter 0.37mm

Diameter 0.38mm

Diameter 0.39mm

Diameter 0.41mm

Diameter 0.43mm

Diameter 0.45mm

Diameter 0.47mm

Diameter 0.49mm

Diameter 0.51mm

Diameter 0.54mm

Diameter 0.58mm

 

Note: The product is for lab research use only (RUO). Not for Human Use. 

 

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