Phospho-AKT1 (Ser473) Monoclonal Antibody

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Product Name Elabscience Phospho-AKT1 (Ser473) Monoclonal Antibody
Catalog No. E-AB-21336
Pack Size 200uL/120uL/60uL
Brand Elabscience Bionovation Inc.
Product Detail Phospho-AKT1 (Ser473) Monoclonal Antibody is a Mouse Monoclonal Antibody to Phospho-AKT1 (Ser473) Monoclonal
Features
Host: Mouse

Application: WB, IHC-p

Species reactivity: Human

Concentration: 1 mg/mL

Immunogen: Synthetic Peptide of Phospho-Akt (Ser473)

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Application: The product is for laboratory research use only. Not for any other use.

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.