Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human Proteinase 3/PR3
Buffer: PBS with 0.01% thiomersal,50% glycerol,pH7.3.
Application: The product is for laboratory research use only. Not for any other use.
Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro. By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177.
