Recombinant Glucocorticoid Receptor Monoclonal Antibody

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Product Name Elabscience Recombinant Glucocorticoid Receptor Monoclonal Antibody
Catalog No. E-AB-81561
Pack Size 100uL/50uL/
Brand Elabscience Bionovation Inc.
Product Detail Recombinant Glucocorticoid Receptor Monoclonal Antibody is a RabbitRabbit Monoclonal Antibody to Recombinant Glucocorticoid Receptor Monoclonal
Features
Host: Rabbit

Application: WB, IF

Species reactivity: Human, Mouse, Rat

Concentration: 300 ug/mL

Immunogen: Recombinant protein of mouse Glucocorticoid Receptor

Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Application: The product is for laboratory research use only. Not for any other use.

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay . Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546).