Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody

Add to Enquire list

Product Name Elabscience Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody
Catalog No. E-AB-81487
Pack Size 100uL/50uL/
Brand Elabscience Bionovation Inc.
Product Detail Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody is a RabbitRabbit Monoclonal Antibody to Recombinant Transcription Factor 7 Like 2 Monoclonal
Features
Host: Rabbit

Application: WB, IHC-P

Species reactivity: Human

Concentration: 300 ug/mL

Immunogen: A synthetic peptide of human TCF-4

Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

Application: The product is for laboratory research use only. Not for any other use.

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.